坂口志文氏ノーベル賞受賞｜制御性T細胞の発見とその意義

<div class&equals;"prose text-pretty dark&colon;prose-invert inline leading-relaxed break-words min-w-0 &lbrack;word-break&colon;break-word&rsqb; prose-strong&colon;font-medium">&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文氏のノーベル賞受賞は、医学界に革新をもたらした「制御性T細胞（Treg）」の発見に端を発します。<&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">制御性T細胞は、免疫が自分を攻撃しすぎないようにコントロールする役割を持ち、自己免疫疾患やがん治療この記事では、坂口志文氏の新人と受賞理由、Treg細胞の働き、その研究の社会的意義や今後の応用可能性、さらに氏の人物像や家族について、キーワードを盛り込みつつ詳しく解説します。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;bbc&period;com&sol;japanese&sol;articles&sol;cn83ed9n5wwo"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">BBC<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus;4<&sol;span><span dir&equals;"auto">&ZeroWidthSpace;<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<hr class&equals;"bg-subtle h-px border-0" node&equals;"&lbrack;object Object&rsqb;" &sol;>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0 md&colon;text-lg &lbrack;hr&plus;&amp&semi;&rsqb;&colon;mt-4" id&equals;""><span dir&equals;"auto">坂口志文ノーベル賞受賞の概要と賞<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">このセクションでは、坂口志文氏のノーベル賞受賞理由、業績研究、収益について解説します。<&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">坂口志文のノーベル賞受賞理由と2025年の受賞内容（ノーベル賞、制御性T細胞、treg）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文氏は2025年、ノーベル生理学・医学賞を受賞しました。 受賞理由は「末梢免疫寛容に関する発見」で、免疫が自己と非自己を正しく区別し、自己免疫疾患の発症を防ぐ仕組みを明らかにしたことが特に評価されました。 彼が発見した制御性T細胞（Treg）は、免疫反応を「ブレーキ」する細胞として知られています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;jp&period;reuters&period;com&sol;world&sol;japan&sol;2CX4MNOLBNIM5IICUCZB3TRBAE-2025-10-06&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">ロイター<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">1<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">この功績によって、アレルギーや１型糖尿病、がんなど様々な疾患の治療法開発に新しい道が拓かれています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed" aria-label&equals;"2025年ノーベル生理学・医学賞に坂口志文・大阪大特任教授ら &period;&period;&period;"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;tokyo-np&period;co&period;jp&sol;article&sol;440793"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">東京新聞<&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">学歴・経歴と大阪大学での特任教授就任（出身高校&comma; 大阪大学&comma; 特任教授&comma; 特任教授）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文氏は滋賀県長浜市生まれ、父親が校長を務め長浜北高校を卒業後、京都大学医学部に進学。医師免許取得後は臨床よりも生命の根本原理を追求する基礎医学研究の道へ向かいました。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;iwatsuki-koukou-dousoukai&period;jp&sol;2025&sol;10&sol;06&sol;sakaguchi&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">岩槻高校同窓会<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">1<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">愛知県がんセンター研究所での研究を皮切りに、ジョンズ・ホプキンス大学やスタンフォード大学など海外でも掘っています。1983年に京都大学から医学博士号を取得しています。その後、大阪大学で特任教授となり、制御性T細胞の発見を果たしました。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed" aria-label&equals;"【坂口志文】Wikiハイスクール！結婚や妻&lpar;嫁&rpar;･子供などの家族構成！"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;iwatsuki-koukou-dousoukai&period;jp&sol;2025&sol;10&sol;06&sol;sakaguchi&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">岩槻高校同窓会<&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">主な受賞歴と栄典（ノーベル賞候補、文化勲章、紫綬賞章、クラフォード賞）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口氏はノーベル賞のみならず、文化勲章や紫綬賞章の受章歴があり、免疫学分野で世界的な評価を確立しています。 クラフォード賞を始めとした数々の国際的な賞にも輝いており、長年にわたる研究成果が広く認められています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;mainichi&period;jp&sol;articles&sol;20251006&sol;k00&sol;00m&sol;040&sol;259000c"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">毎日<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">1<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<hr class&equals;"bg-subtle h-px border-0" node&equals;"&lbrack;object Object&rsqb;" &sol;>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0 md&colon;text-lg &lbrack;hr&plus;&amp&semi;&rsqb;&colon;mt-4" id&equals;"ttreg"><span dir&equals;"auto">制御性T細胞（Treg）とは何かと研究内容<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">ここでは制御性T細胞（Treg）の基本的な役割や坂口氏の主な研究内容、臨床応用の可能性について説明します。<&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">制御性T細胞の機能と免疫抑制の理論（制御性T細胞&comma; tregいつ&comma; treg論文&comma; 免疫疾患&comma; I型糖尿病）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">制御性T細胞（Treg）は、自己免疫疾患を防ぐために必要な「免疫のブレーキ役割」として働きます。1995年に坂口志文氏が初めてその存在を発表しました。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;ncc&period;go&period;jp&sol;jp&sol;ri&sol;division&sol;cancer&lowbar;immunology&sol;project&sol;020&sol;20170908150858&period;html"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">NCC<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">2<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">Treg細胞は、自己を攻撃するT細胞を抑制し、免疫のバランスを見極めます。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;riken&period;jp&sol;press&sol;2017&sol;20170802&lowbar;1&sol;index&period;html"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">理研<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">1<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">また、TregはCTLA-4やインターロイキンなど複数の分子を用いた多様な抑制メカニズムを持っていることも明らかになっている。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;resou&period;osaka-u&period;ac&period;jp&sol;ja&sol;story&sol;2013-1&sol;201312&lowbar;01"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">resou&period;osaka-u<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">2<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">坂口志文の研究室と論文紹介（研究室&comma; 論文&comma; 3dマトリックス）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口氏の研究室では、制御性T細胞の発生や機能分子に関する基礎研究に加え、難治性自己免疫疾患やがん免疫療法の新たな戦略開発が進められています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed" aria-label&equals;"制御性T細胞は何をつたえているのか"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;osaka-u&period;ac&period;jp&sol;ja&sol;news&sol;storyz&sol;storyz&lowbar;research&sol;201312&lowbar;special&lowbar;issue01"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">大阪大学<&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">特にTregの動作や機能欠陥に焦点を当てた論文は、世界中で高い評価を受け、多くの学術誌に掲載されてきました。3Dマトリックスを活用した実験モデルなど、免疫の動態をより詳細に解析する手法も導入されています。<&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">臨床応用の可能性とノーベル賞関連価値（ベル賞価値&comma; ノーベル賞関連株&comma; ノーベル賞関連銘柄&comma; アンジェノー&comma; ifrec&comma; ips）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">制御性T細胞の理解が進んでいますので、iPS細胞やがん免疫療法、炎症制御など幅広い分野への応用可能性が拡大しています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed" aria-label&equals;"細胞性免疫・制御性T細胞"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;jaci&period;jp&sol;patient&sol;immune-cell&sol;immune-cell-05&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">ジャシ<&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口氏がセンター長を務めた大阪大学免疫学フロンティア研究センター（IFReC）は、バイオ・医薬系スタートアップのアンジェス等、ノーベル賞関連銘柄として注目されています。 今後の臨床応用や新薬開発の進展次第で、経済的効果も大きく期待されています。<&sol;span><&sol;p>&NewLine;<hr class&equals;"bg-subtle h-px border-0" node&equals;"&lbrack;object Object&rsqb;" &sol;>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0 md&colon;text-lg &lbrack;hr&plus;&amp&semi;&rsqb;&colon;mt-4" id&equals;""><span dir&equals;"auto">坂口志文の人物像と家族について<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">このセクションでは坂口氏の家族構成や人物像、確信について紹介します。<&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">家族構成と妻・子供の紹介（妻&comma; 子供&comma; 家族構成&comma; 兄弟&comma; 兄）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文氏は、慎重で学問熱心な父のもとで育ちました。妻の教子さんとは長年連れ添っていて、家庭でも穏やかで前向きな性格で知られています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;nikkei&period;com&sol;article&sol;DGXZQOUD06AA70W5A001C2000000&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">日経<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">1<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">3人兄弟の次男で、家族には医師や教育者が多いのも特徴です。本人も「冷静で動揺しない」性格と評されています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed" aria-label&equals;"「冷静で揺るがず楽天的な家族」が語る坂口志文氏 大学受験 &period;&period;&period;"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;nikkei&period;com&sol;article&sol;DGXZQOUD06AA70W5A001C2000000&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">日経<&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">出身地・出身高校と高等学校（出身高校&comma; 愛知県がんセンター&comma; 高等学校&comma; かつら）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文（さかぐちしもん）氏は、滋賀県長浜市出身、長浜北高校卒業です。 その後、愛知県がんセンターや屋内の研究機関を経て、世界的な研究者として活躍しました。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;go2senkyo&period;com&sol;seijika&sol;184180&sol;posts&sol;1202280"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">go2senkyo<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">2<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">坂口志文人物柄と信念（信念、温厚な人物）<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口氏は、粘り強く信念を持つ人間として知られています。自己説が認められない時期にも「自分の信じる道」を淡々と、科学への真摯な姿勢を貫きました。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;mainichi&period;jp&sol;articles&sol;20251007&sol;k00&sol;00m&sol;040&sol;090000c"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">毎日<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus; <&sol;span><span dir&equals;"auto">2<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">同僚や弟子からも「温厚」「一歩」「楽天的」と評価されており、研究環境にも良い影響を与えています。<&sol;span><&sol;p>&NewLine;<hr class&equals;"bg-subtle h-px border-0" node&equals;"&lbrack;object Object&rsqb;" &sol;>&NewLine;<h2 class&equals;"mb-2 mt-4 font-display font-semimedium text-base first&colon;mt-0"><span dir&equals;"auto">まとめ｜坂口志文ノーベル賞受賞が示す未来への影響<&sol;span><&sol;h2>&NewLine;<p class&equals;"my-2 &lbrack;&amp&semi;&plus;p&rsqb;&colon;mt-4 &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;inline-block &lbrack;&amp&semi;&lowbar;strong&colon;has&lpar;&plus;br&rpar;&rsqb;&colon;pb-2"><span dir&equals;"auto">坂口志文氏のノーベル賞受賞は、「制御性T細胞」という新たな免疫システムの考え方を世界中に広め、医療とバイオ産業の発展に大きく貢献しようとしています。<&sol;span><span class&equals;"citation inline" rel&equals;"nofollow noopener" data-state&equals;"closed"><a rel&equals;"noopener" class&equals;"inline" target&equals;"&lowbar;blank" href&equals;"https&colon;&sol;&sol;www&period;nikkei&period;com&sol;article&sol;DGXZQOUC00042&lowbar;V01C21A1000000&sol;"><span class&equals;"relative -mt-px select-none whitespace-nowrap -top-px font-sans text-base text-foreground selection&colon;bg-super&sol;50 selection&colon;text-foreground dark&colon;selection&colon;bg-super&sol;10 dark&colon;selection&colon;text-super"><span class&equals;"text-3xs rounded-badge group min-w-4 cursor-pointer text-center align-middle font-mono tabular-nums py-&lbrack;0&period;1875rem&rsqb; leading-snug px-&lbrack;0&period;3rem&rsqb; &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;bg-super dark&colon;&lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-inverse &lbrack;&commat;media&lpar;hover&colon;hover&rpar;&rsqb;&colon;hover&colon;text-white border-subtlest ring-subtlest divide-subtlest bg-subtle"><span class&equals;"relative -mt-px inline-block align-middle max-w-&lbrack;25ch&rsqb; overflow-hidden"><span dir&equals;"auto">日経<&sol;span><&sol;span><span class&equals;"ml-xs -mt-px mr-px inline-block align-middle"><span class&equals;"opacity-50"><span dir&equals;"auto">&plus;4<&sol;span><span dir&equals;"auto">&ZeroWidthSpace;<&sol;span><&sol;span><&sol;span><&sol;span><&sol;span><&sol;a><&sol;span><&sol;p>&NewLine;<&sol;div>&NewLine;<ol>&NewLine;<li><a href&equals;"https&colon;&sol;&sol;www&period;bbc&period;com&sol;japanese&sol;articles&sol;cn83ed9n5wwo">https&colon;&sol;&sol;www&period;bbc&period;com&sol;japanese&sol;articles&sol;cn83ed9n5wwo<&sol;a><&sol;li>&NewLine;<li><a href&equals;"https&colon;&sol;&sol;jp&period;reuters&period;com&sol;world&sol;japan&sol;2CX4MNOLBNIM5IICUCZB3TRBAE-2025-10-06&sol;">https&colon;&sol;&sol;jp&period;reuters&period;com&sol;world&sol;japan&sol;2CX4MNOLBNIM5IICUCZB3TRBAE-2025-10-06&sol;<&sol;a><&sol;li>&NewLine;<li><a 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